The Global E-Mail Economy

The problem with the global economy is that there's always someone awake and sending me e-mail. I get a couple hundred e-mails a day, and in the old days, I could be pretty certain that I wouldn't get more than 10-15 over night, and they usually weren't serious. Now? I get a good half a day's worth of e-mail before I even wake up. How am I supposed to keep up with that?